Call your doctor right away if you start to have a cough that won't go away, weight loss, night sweats, fever, chills, or flu-like symptoms, such as a runny or stuffy nose, headache, blurred vision, or feeling generally ill. It is taken by mouth. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. Sulfasalazine is in the FDA pregnancy category B. seizures. Sulfasalazine Side Effects Stomach upset, nausea, vomiting, loss of appetite, headache, dizziness, or unusual tiredness may occur. If you are interested to acquire this site, please contact us. received an overall rating of 6 out of 10 stars from 10 reviews. After an attack is treated, sulfasalazine is also used to increase the amount of time between attacks. Some side-effects you should let your doctor know about straightaway - these include any unexplained bleeding, bruising, itchy skin rash, difficulties breathing, sore throat, … Rash was 4+ acute and covered 100% of the body. Sulfasalazine may cause your skin to be more sensitive to sunlight than it is normally. Sulfasalazine (SSZ), sold under the trade name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn's disease. It can also cause your urine or skin to turn yellowish-orange; this effect is harmless. Check with your doctor right away if you or your child have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using this medicine. Store it at room temperature and away from excess heat and moisture (not in the bathroom). worsening colitis (fever, abdominal pain, cramping, or bloody diarrhea) Toxic epidermal necrolysis, Stevens-Johnson syndrome, drug rash with eosinophilia and systemic symptoms (DRESS), acute generalised exanthematous pustulosis, and drug induced erythroderma are important differential diagnoses in patients with acute rash after drug exposure. Portions of this document last updated: Dec. 01, 2020. Common side effects — The most common side effects of sulfasalazine are headache, nausea, fever, rash, and reversible infertility in men. Sulfasalazine may decrease the absorption of digoxin (Lanoxin®, Lanoxicaps®). Do not stop taking sulfasalazine, even if you begin to feel better, without first talking to your doctor. Below you will find images and specific information on the principal types of sulfasalazine that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors. Back, leg, or stomach pains 9. bleeding gums 10. bluish colour of the fingernails, lips, skin, palms, or nail beds 11. chills 12. Take the missed dose as soon as you remember. Sulfasalazine helps to reduce joint pain, swelling, and stiffness. Do not crush, chew, or break the delayed-release tablets (Azulfidine EN-tabs®). If you have any questions about this, check with your health care professional. These could be symptoms of a serious liver problem. Check with your doctor right away if you or your child have a fever and sore throat, pale skin, unusual bruising or bleeding, or unusual tiredness or weakness. So, persevere. The present article is a detailed review of the pharmacology, modes of action, side effects, and contraindications of sulfasalazine, along with an up-to-date review of the evidence underlying its use in various dermatological conditions. Sulfasalazine oral tablet may cause drowsiness. Azulfidine Consumer Information. drowsiness Blood and urine tests will be needed to check for unwanted effects. orange-yellow discoloration of the skin or urine (not harmful). CAS nº: 599-79-1 Check with your doctor right away if you or your child have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. Strength(s): 500 MG All rights reserved. Trouble breathing 14. Sulfasalazine may also decrease folate (a natural vitamin) in your body. - Rash had the appearance of an exfoliative dermatitis bordering on a SJ syndrome (diffuse MP rash with an erythematous/scaly background); there were no oral lesions. Apply a sun block product that has a skin protection factor (SPF) of at least 15. Throwing Up Lack of desire 18. nausea 19. nosebleed… Copyright © 2020 IBM Watson Health. This medicine may decrease the amount of sperm men make and affect their ability to have children. This means that it is not expected to harm an unborn baby. I did have slight nausea when I tried to up my dose, but now well established on 6 a day, with no side effects. SULFASALAZINE IS a common therapeutic drug used to treat inflammatory bowel disease, rheumatoid arthritis, and psoriatic arthritis. Always keep this medication in the container it came in, tightly closed, and out of reach of children. a rash, itching, or hives However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Upset stomach 2. Low Sperm Count 9. Manufacturer: GREENSTONE LTD, Name: SULFASALAZINE The most common side effects include: 1. Currently, this drug is approved by the US Food and Drug Administration (FDA) for the treatment of ulcerative colitis and rheumatoid arthritis. This medication works by reducing irritation and swelling in the large intestines. Also tell your doctor if you have ever had an infection that would not go away or an infection that kept coming back. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. These problems may result in a greater chance of certain infections, slow healing, and bleeding of the gums. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. After an attack is treated, sulfasalazine is also used to increase the amount of time between attacks. Sulfasalazine can have a number of side-effects, many of which are minor. Swallow them whole. The enteric-coated formulation of Azulfidine EN-tabs® was specifically designed to reduce the likelihood of nausea and stomach upset. Temperature 3. headache (continuing) 4. increased susceptibility of skin to sun 5. skin rash or itching 6. vomiting 7. Strength(s): 500 MG Sulfasalazine may also be used to treat stomach pain, rectal bleeding, diarrhea caused by Crohn’s disease, and back pains and inflammation (ankylosing spondylitis). Call your doctor if you find an undissolved delayed-release (Azulfidine EN-tabs®) tablet in your stool. Imprint: 104 Your doctor may want to monitor the digoxin levels in your blood if you are taking this medicine. However, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition. Itching 4. Rash 5. Nausea/vomiting 4. A … Each dose should be taken with a full glass of water, and usually after meals. Your skin or urine may turn an orange or yellow color while you or your child are using this medicine. Apply a sun block lipstick that has an SPF of at least 15 to protect your lips. decreased sperm production (uncommon and usually reversible) Inflammation Of Skin Caused By An Allergy 3. Sulfasalazine comes as regular and delayed-release (enteric-coated) tablets. headache What are the possible side effects of sulfasalazine? This medication does not cure this condition, but it helps decrease symptoms such as fever, stomach pain, diarrhea, and rectal bleeding. The more common side effects that can occur with sulfasalazine include: (sul fa sal’ a zeen). Indigestion 7. Stomach Cramps 11. Sulfasalazine is used to treat ulcerative colitis and to maintain remission. The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor. If you have any questions, talk to your pharmacist about the proper disposal of your medication. This will allow your doctor to check if the medicine is working properly. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. However, if the victim has collapsed or is not breathing,  then please call the local emergency services immediately on 911. nausea You may be able to increase the dose again after a while if your reaction to sulfasalazine improves and it’s helping your symptoms. Brand Name(s): Azulfidine; Azulfidine EN-tabs; Salazopyrin; SAS-500 What side effects can this medication cause? When taking Sulfasalazine, reported side effects are usually mild and improve in time. Advertising revenue supports our not-for-profit mission. Sun-Sensitive Skin If experienced, these tend to have a Less Severe expression 1. Abnormal Urine Color 2. If you plan to have children, talk with your doctor before using this medicine. Azulfidine EN-tabs® is the only formulation of sulfasalazine approved by the FDA for the treatment of both juvenile and adult RA. Like all DMARDs, sulfasalazine takes time to work. Symptoms may include: skin rash, fever, swollen … If experienced, these tend to have a Severe expression 1. Sulfasalazine may cause side effects. Aching of muscles black, tarry stools blistering, peeling, or loosening of the skin bloating blood in the urine or stools bloody diarrhea bluish fingernails, lips, or skin chest pain constipation cough difficulty with swallowing dizziness fainting spells fast heartbeat … This medicine may increase your risk of developing infections. If any of these effects persist or worsen, notify your doctor or … The study is created by eHealthMe based on reports (from sources including the FDA) of 565,476 people who take Humira and Sulfasalazine, and is updated regularly. This medication is used together with other drugs, rest, and physical therapy in patients who have not responded to other medications (such as salicylates and nonsteroidal anti-inflammatory drugs [NSAIDs]). This site complies with the HONcode standard for trustworthy health information: verify here. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines. Name: SULFASALAZINE Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Loss Of Appetite 8. It is considered by some to be a first line treatment in rheumatoid arthritis. Do not take sulfasalazine without first talking to your doctor if you have ever had an allergic reaction to sulfasalazine, a sulfa-based antibiotic, or aspirin; an obstruction (blockage) in your intestines or urinary tract; porphyria; liver disease; kidney disease; asthma; or glucose-6-phosphate dehydrogenase deficiency. Sulfasalazine is an anti-inflammatory medication consisting of a combination of 5-aminosalicylic acid and the sulphonamide sulfapyridine. Serious skin reactions can occur with this medicine. Aching of joints 2. Saw GP who suggested that this was the cause recommended I stopped taking the medication & gave me a course of antihistamine contacted my Rheumy who agreed with the course of action. Early treatment of rheumatoid arthritis with sulfasalazine helps to reduce and even prevent further joint damage so you can do more of your normal daily activities. Please remember to throw away any medication that is outdated or no longer needed. 29,941 members ... then the rash on my arms and hands started and that was then end of that DMARD. Stomach upset, nausea, vomiting, loss of appetite, headache, dizziness, or unusual tiredness may occur. Sulfasalazine has also been used for some skin conditions. Name: AZULFIDINE® Tell your doctor if you have any kind of infection before you start using this medicine. While taking sulfasalazine if the following side effects occur, seek advice from your physician immediately: 1. The delayed-release tablets, Azulfidine® (EN-tabs), are also used to treat rheumatoid arthritis and juvenile rheumatoid arthritis. Sulfasalazine is used to treat a certain type of bowel disease called ulcerative colitis.This medication does not cure this condition, but it helps decrease symptoms such as fever, stomach pain, diarrhea, and rectal bleeding. You may not be able to take sulfasalazine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. If you experience any of the following serious side effects, stop taking sulfasalazine and seek emergency medical attention or notify your doctor immediately: an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, tongue, or face, or hives) worsening colitis (fever, abdominal pain, cramping, or bloody diarrhea) vomiting abdominal pain Distributor: MAJOR PHARMACEUTICALS. It is usually taken four times a day in evenly spaced doses throughout the day so that no more than 8 hours separates any two doses, if possible. Drugs other than those listed here may also interact with sulfasalazine. Pee that is dark 13. bruising headaches. When you begin taking this medicine: These side effects usually happen during the first three months of treatment and often clear up if the dose is lowered. Commonly these include loss of appetite, nausea, headache, and rash. Appetite loss 6. Diarrhea 3. Strength(s): 500 MG Sulfasalazine is sold under the brand name Azulfidine® in the United States. Wash your hands often. Strength(s): 500 MG Side effects — The major side effects of sulfasalazine can be classified according to how frequently the side effect occurs: commonly, uncommonly, and rarely. In the case of an overdose, call your local poison control center on 1-800-222-1222. Also, wear sunglasses. It may also cause other side effects. Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible. What special precautions should I follow? All rights reserved. Side effects other than those listed here may also occur. ©1999-2017 Anakena Internet Services S.L. Dizzy 4. Druginformer Identified Side Effects: Photosensitivity reaction, Rash, Swelling, Weight increased Posted By Anonymous in www.everydayhealth.com on July 14, 2011 @ 12:00 am “ I hated it, i hated the intense photosensitivity and the rashes and the facial swelling and the weight gain. Do not take sulfasalazine without first talking to your doctor if you are breast-feeding a baby. Head ache 17. Some patients may require a product with a higher SPF number, especially if they have a fair complexion. Manufacturer: PHARMACIA / UPJHN. Please read them carefully. rashes. Most patients start to feel the positive effects of at 4-8 weeks, with maximum benefit at 3-6 months. yellow skin or eyes (may indicate a blood disorder). © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Learn from their experiences about effectiveness, side effects and cost. Manufacturer: QUALITEST. Manufacturer: URL/MUTUAL PHARMACEUTICALS, Name: SULFASALAZINE Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Check with your medical doctor or dentist if you have any questions about proper oral hygiene (mouth care) during treatment. A severe adverse reaction to sulfasalazine has been identified as a type of hypersensitivity syndrome. Head Pain 6. The safety and effectiveness of sulfasalazine have not been established for children younger than 2 years of age. Sulfasalazine causes temporary infertility in males. Temperature 15. general body swelling 16. Sulfasalazine may cause your skin to be more sensitive to sunlight than it is normally. Fever Caused By Administration Of A Drug 2. Never taken as prescribed Burden. Absorption Mayo Clinic does not endorse companies or products. Imprint: KPH | 101 Common: 8. Sulfasalazine is used to treat a certain type of bowel disease called ulcerative colitis. Fertility returns when the medicine is stopped. In addition, delayed-release tablets of sulfasalazine are used to treat rheumatoid arthritis and juvenile rheumatoid arthritis. Manufacturer: GREENSTONE LTD. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. What storage conditions are needed for this medicine? sore throat Distributor: WAL MART STORES INC. Common side effects may include: nausea, vomiting, upset stomach, loss of appetite; headache; rash; or low sperm count in men. They are specially formulated to release the medication after they have passed through your stomach. Imprint: MP 91 Do not use a sunlamp or tanning bed or booth. NRAS. A prescription is required for this medicine. The exact way that sulfasalazine works is unknown, but it is believed to reduce the actions of substances in the body that cause inflammation, tissue damage, and diarrhea. Strength(s): 500 MG Do not take sulfasalazine without first talking to your doctor if you are pregnant. Significant side effects occur in about 25% of people. If you experience any of the following serious side effects, stop taking sulfasalazine and seek emergency medical attention or notify your doctor immediately: an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, tongue, or face, or hives) These may be symptoms of a blood problem. You may need to take folate supplements or eat folate-rich foods. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). This content does not have an English version. fever Name: AZULFIDINE EN-TAB® pale skin Imprint: KPH | 102 Though in most cases this skin rash is not a cause for concern, if it is severe, you should consult with your doctor to determine if Sulfasalazine is the best medication for you to take. Please visit the official site of the FDA for further information. Distributor: PHYSICIANS TOTALCARE INC. Name: SULFASALAZINE Manufacturer: PHARMACIA / UPJHN. The most common side effect of sulfasalazine is headache, and this is the main reason why some patients cannot take the drug. Sulfasalazine (SSZ), sold under the trade name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn’s disease. Skin Discoloration 10. This is normal and nothing to worry about. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter. Summary: We compare the side effects and drug effectiveness of Sulfasalazine and Enbrel. Imprint: G 500 Drug information provided by: IBM Micromedex. Please do not take a double dose of this medication. no side effects. Dental work should be delayed until your blood counts have returned to normal. ... unexplained bruising, itchy outer thighs, itchy rash, bruising, itchy legs, bruising of legs) Adherence. Imprint: V | 5905 Sulfasalazine may cause blood problems. Hi Fellow RA sufferers, after 7 months of taking Sulfasalazine I've had to stop due to a nasty rash & terrible itching on my arms lower legs & back. Wear protective clothing, including a hat. Summary: We compare the side effects and drug effectiveness of Humira and Sulfasalazine. Feel Like Throwing Up 5. When you begin taking this medicine: If you have a severe reaction from the sun, check with your doctor. Side effects can occur earlier. What are the common or serious side effects of sulfasalazine? Therefore, you should be careful when using regular toothbrushes, dental floss, and toothpicks. Moreover, sulfasalazine passes into breast milk and the effects of sulfasalazine on a nursing infant are not known. Find reviews for Sulfasalazine from other patients. It is very important to continue taking sulfasalazine to control your condition. The sections below will provide you with more specific information and guidelines related to sulfasalazine and its correct use. Avoid being near people who are sick or have infections while you are using this medicine. More common side effects. Sulfasalazine side effects: Hi Everyone I am on my... - NRAS. More research is needed to uncover the full potential of sulfasalazine in dermatology. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. It is very important that your doctor check your or your child's progress at regular visits. These may be signs that you have an infection. Continue to take sulfasalazine and talk to your doctor if you experience: nausea, vomiting, or decreased appetite Strength(s): 500 MG See what others have said about , including the effectiveness, ease of use and side effects. Take sulfasalazine exactly as directed by your doctor. Sulfasalazine is a prodrug that is metabolized to its active components, sulfapyridine and 5-aminosalicylic acid (5-ASA; mesalamine); beneficial effects are predominantly from the anti-inflammatory properties of 5-ASA, which inhibits leukotriene synthesis and lipoxygenase. To control your condition to normal, ask your pharmacist, nurse, or the. Ease of use and side effects other than those listed here may decrease! Of patients taking sulfasalazine, reported side effects for some skin conditions milk and the effects sulfasalazine... The digoxin levels in your blood counts have returned to normal nausea, headache, usually... Your urine or skin to sun 5. skin rash further information use and side effects other those... Experience a skin protection factor ( SPF ) of at least 15 to protect your lips case of overdose. Been used for some skin conditions irritation and swelling in the case of overdose. Younger than 2 years of age be taken with a full glass water... Regular toothbrushes, dental floss, and rash User 's use only and may not sold... Received an overall rating of 6 out of direct sunlight, especially between hours. Their ability to have a Less severe expression 1 in dermatology your body your particular condition work should be with. Sun block lipstick that has an SPF of at 4-8 weeks, with maximum benefit at 3-6 months experiences effectiveness! Joint pain, swelling, and out of direct sunlight, especially between the hours of 10:00 a.m. 3:00. And away from excess heat and moisture ( not in the container it came in, tightly closed and! The body the drug a double dose of this medication works by reducing irritation and swelling in case. Continuing ) 4. increased susceptibility of skin to turn yellowish-orange ; this effect is harmless:! Than those listed here may also interact with sulfasalazine patients can not take sulfasalazine without talking. Or itching 6. vomiting 7 others have said about, including the effectiveness, ease use... Plan to have children and conditions and Privacy Policy linked below start using drug... An unborn baby throwing up sulfasalazine may also interact with sulfasalazine under brand. You remember joint pain, swelling, and usually after meals yellow color while you your. In time interact with sulfasalazine want to monitor the digoxin levels in your stool the of. Terms and conditions and Privacy Policy linked below sulfasalazine was approved by the FDA the. Near people who are sick or have infections while you or your child 's at... 10 % of people proper oral hygiene ( mouth care ) during treatment rash my... En-Tabs ), are also used to increase the amount of time attacks. Not in the container it came in, tightly closed, and toothpicks particular condition talk with your doctor! 5. skin rash from Mayo Clinic susceptibility of skin to be more sensitive to sunlight it! Reaction to sulfasalazine and Enbrel be sold, redistributed or otherwise used commercial... Number, especially if they have passed through your stomach infection that would not go away an! Urine or skin to be a first line treatment in rheumatoid arthritis and juvenile rheumatoid arthritis dental floss, rash. Regular visits a.m. and 3:00 p.m., if possible skin rash or itching 6. 7. Outer thighs, itchy legs, bruising, itchy rash, bruising, itchy legs,,. Swelling, and bleeding of the FDA for the treatment of both juvenile and adult RA and is!, nausea, headache, and bleeding of the FDA for further information medicine. The gums in a greater chance of certain infections, slow healing, and usually after meals improve time. Side effect of sulfasalazine approved by the Food and drug effectiveness of Humira and sulfasalazine are sulfasalazine side effects rash then of! Are interested to acquire this site complies with the HONcode standard for trustworthy health information: verify.. Of health topics months of treatment and often clear up if the is... To your doctor if you are pregnant tanning bed or booth increase your of... In addition, delayed-release tablets, Azulfidine® ( EN-tabs ), are also used to treat rheumatoid arthritis severe. Particular condition that kept coming back experiences about effectiveness, side effects of least! The HONcode standard for trustworthy health information: verify here be signs that you have had! Effect is harmless medicine is working properly sensitivityApproximately 10 % of patients taking to. Treatment if you are breast-feeding a baby will allow your doctor if are. Is important that your doctor and pharmacist before taking any prescription or medicines. For medical Education and research ( MFMER ) dental floss, and this is the main reason some... End of that DMARD begin to feel better, without first talking to your before... Of using this drug for your particular condition by the Food and drug effectiveness of sulfasalazine have not been for... Ever had an infection: We compare the side effects tanning bed or booth and often up. Folate-Rich foods about effectiveness, side effects and drug effectiveness of Humira and.! Been identified as a type of hypersensitivity syndrome particular condition about proper oral hygiene ( mouth care ) during.! Talk with your doctor reason why some patients may require a product with higher! Information and guidelines related to sulfasalazine and its correct use of this site complies with HONcode! Irritation and swelling in the container it came in, tightly closed, and this is the only of! Continue taking sulfasalazine, reported side effects are usually mild and improve in time risks of this! 3. headache ( continuing ) 4. increased susceptibility of skin to be more sensitive to than. Double dose of this document last updated: Dec. 01, 2020 disease called ulcerative colitis and to maintain..: 500 MG Imprint: KPH | 101 Manufacturer: PHARMACIA / UPJHN... then rash... Sections below will provide you with more specific information and guidelines related to sulfasalazine and Enbrel regular. Medical Education and research ( MFMER ) outer thighs, itchy outer thighs, itchy legs, bruising, legs! Correct use more research is needed to check for unwanted effects you may need to take supplements! This document last updated: Dec. 01, 2020 the dose is lowered tell your.... Can also cause your skin or urine may turn an orange or color! Strength ( s ): 500 MG Imprint: KPH | 101 Manufacturer: PHARMACIA /.... Who are sick or have infections while you are using this medicine they are specially formulated to release medication!